HIF and NF-kappaB Crosstalk
The Hypoxia Inducible Factor (HIF) transcription factor family are best known to respond to changes in oxygen availability. Similarly, NF-kappaB transcription factors are known regulators of the cell's response to inflammation. Our research has revealed a complex and intricate crosstalk between these transcription factors in hypoxia and inflammation.
Chromatin senses changes in oxygen availability
Chromatin is a structure composed of DNA and histone proteins. Its dynamic structure is important for numerous processes in the cell from DNA replication to transcriptional activation and DNA repair. In response to changes to oxygen availability a number of histone methylation marks change, due to the changes in activity of a class of histone demethylases called JmjC-domain containing enzymes.
The interplay between Prolyl-Hydroxylases (PHDs) and the Cell Cycle
PHDs are best known for their role in controlling the levels of the transcription factor family HIF (Hypoxia Inducible Factor). However, our research has revealed that PHDs have other targets in the cells, and some of these are directly involved in the control and progression of the cell cycle.
